The Binding of Isaac: Repentance+

The last 49

Guide to the missing achievements of this Steam profile, on the way to Dead God.

592 of 641 unlocked on Steam 92.4%

Steam data from

Next up

Order of attack: each step saves a run or a replay later. Times are active play; the Dailies run alongside everything.

  1. Step 1. Daily chain: 5 Daily wins in a row first (skip risky days, never force quit), then 7 trophies, then 31 entries; mods and console offevery day3 left
    Time
    6-12 h of play over ≥31 days
    • Before each scored attempt, read the day’s goal and character. Skip a day you are likely to lose (Tuesday Tainted, Friday Hard): skipping does not break the streak, losing does CARGO1. wiki
    • Never Alt+F4 or force quit: since 1.9.7.10 it resets the streak N-9710. Practice after your attempt is safe and good for scouting the seed N-9711. R+ patch
    • After 5 wins in a row (The Marathon), 2 more trophies give Broken Modem; from then on a quick death each day is enough for Dedication CARGO1. wiki
    • Mods and the debug console off, or the Daily will not start DAILYS-DCONS. wiki
    • Thursday (Home, Beast) has no trophy: whether that win counts toward Broken Modem is not known DAILY. unconfirmed
    • The Marathon wins in a row0 / 5
    • Broken Modem trophies0 / 7
    • Dedication Dailies played0 / 31

    Targets: 5 wins in a row, 7 trophies, 31 Dailies played. Steam does not publish these counts, so the page keeps them in this browser; an unlock on Steam fills its line.

    Open Daily

  2. Step 2. Online: back up the save, own lobby, solo Multiplayer Daily first; a regular lobby run only if Win Online did not dropnow3 left
    Time
    1-3 h
    • Back up the save first: online is a beta and can corrupt save data ONLINES-WIPE. wiki
    • Mods off, restart the game, create your own lobby and start alone. A player who joins a run in progress gets no achievements ACHN-RP. wiki
    • First the Multiplayer Daily, solo: kill the day’s goal S-SOLO. Then check Steam; if nothing shows, open Main menu → Stats → Secrets S-SECRETS. community
    • If Play Online and Win Online dropped too, skip the regular online run. Otherwise one short lobby run (Azazel, for example) to the nearest ending, such as Isaac or Satan without the Polaroid/Negative TIPS. unconfirmed
    • Play that day’s solo Daily before the online one: whether online Dailies count toward the Daily achievements and the streak is not known. unconfirmed

    Open Online

  3. Step 3. 5 Nights streak: five wins in a row with five different regular characters, one of them Azazel → The Lamb under 20:001 left
    Unlocks
    5 Nights at Mom’s, ZIP!
    Time
    4-7 h
    • Five wins in a row with five different regular characters, no resets in between. Any ending counts; the shortest is Isaac or Satan without the Polaroid/Negative TIPS. wiki
    • One of the five: Azazel → The Lamb under 20:00 of in-game time for ZIP!; Normal is fine S-ZIPTG-RP26. Past 20:00, still finish: the streak matters more. community
    • Marbles and Huge Growth: take them only if the combination is already there. Do not sacrifice the streak for RNG goals. wiki
    • Challenges between regular runs do not break the streak TIPS. wiki

    Open 5 Nights at Mom’s

  4. Step 4. Targeted Greed resets for Marbles and Huge Growth, then Pica Run and the other challenges7 left
    Unlocks
    Marbles, Huge Growth, Pica Run, 5 challenges
    Time
    5-10 h
    • Marbles: Lazarus in Greed mode, reset until the starting pill is Gulp!; the Greed shop sells pills too. Placebo + identified Gulp! is the best combo S-GULP1S-GULP2PLACEBO. community
    • Huge Growth: the same Lazarus Greed reset for One makes you larger, plus Placebo (6-room recharge) S-HG22PLACEBO. community
    • Pica Run opens right after Marbles; restart it until Cancer, Curved Horn or Crystal Key at the start CARGO1PICA. Then BRAINS!, Hot Potato, Red Redemption and DELETE THIS. wiki

    Open In-runOpen Challenges

  5. Step 5. Tainted Cain Run B (Sheol → Satan → The Lamb) with It’s the Key: the bag collects hearts, coins and bombs1 left
    Unlocks
    It’s the Key, Tainted Cain’s Satan and Lamb marks
    Time
    1-3 h
    • Tainted Cain on Hard: Sheol → Satan → Dark Room (Negative) → The Lamb. Never touch a heart, coin or bomb yourself; swing the bag to collect them TIPS. wiki
    • If It’s the Key fails, finish anyway: the Satan and Lamb marks still count toward Gilded Key TIPS. No separate It’s the Key attempt and no Azazel run for it. wiki

    Open Tainted Cain runsOpen It’s the Key

  6. Step 6. Tainted ??? (3 runs)2 left
    Unlocks
    Dingle Berry, Ring Cap, Soul of ???
    Time
    3-6 h
    • Runs A, B, C. Check the Run A gate on the way down. wiki
    T. ??? 2 left

    Run A gate

  7. Step 7. Tainted Forgotten (5 runs), then Tainted Eden (2 runs)9 left
    Unlocks
    9 Tainted unlocks
    Time
    9-16 h
    • Tainted Forgotten: A, B, C, D, E. Tainted Eden: C, then D (the Beast ends the run, so it goes last). wiki
    T. Forgotten 7 leftT. Eden 2 left

    Run A gate

  8. Step 8. Tainted Lazarus (5 runs): Flip early helps the later collection cleanup7 left
    Unlocks
    7 Tainted unlocks
    Time
    8-14 h
    • Runs A to E; Flip (Delirium, Run A) is the most valuable unlock of the step. wiki
    T. Lazarus 7 left

    Run A gate

  9. Step 9. The rest of Tainted Cain: Runs A, C, D, E7 left
    Unlocks
    7 Tainted unlocks
    Time
    7-13 h
    • Runs A, C, E, then D: the Beast ends the run, so it goes last. Satan and Lamb are already in from step 5. wiki
    T. Cain 7 left

    Run A gate

  10. Step 10. Tainted Jacob (5 runs)7 left
    Unlocks
    7 Tainted unlocks
    Time
    10-22 h
    • Tainted Jacob: A, B, C, E, then D (the Beast ends the run). The hardest character left, so it comes last, with the most experience. wiki
    T. Jacob 7 left

    Run A gate

  11. Step 11. Finish: Death Certificate, then the Death Certificate item and the collection2 left
    Time
    4-12 h
    • Death Certificate: if every mark is done but it is missing, open Stats → Secrets S-DC. community
    • Then the Death Certificate item, Spindown Dice and Tainted Cain crafting close the collection for Dead God DCISPINBOC. wiki
    • Death Certificate needs Hard marks for all 34 characters CARGO2. The 6 Tainted in the plan get theirs on the way (play them on Hard). If it still doesn’t drop after the last Tainted run, a Normal-only mark is left on one of the other 11 Tainted: their post-its are the only place to see it, and Stats → Secrets resyncs S-DC. wiki

    Open Death CertificateOpen Dead God

Best value for the effort

Reward value times ease, among goals you can start today. Full list in Rewards.

  1. Flip T. Lazarus, Delirium9 of 10
  2. Bag of Crafting T. Cain, Delirium8 of 10
  3. Gold Pill T. Cain, Mega Satan8 of 10

Bottom line. Start the Dailies now: they take at least 31 days, the longest stage. Get the online achievements solo through your own lobby, after a save backup. Then the 5-win streak (with ZIP! inside it), targeted Greed resets and the challenges, Tainted Cain’s Sheol run together with It’s the Key, and the Tainted characters: Tainted ??? → Tainted Forgotten → Tainted Eden → Tainted Lazarus → the rest of Tainted Cain → Tainted Jacob. Play everything on Hard: Death Certificate requires Hard marks for all 34 characters.

Daily

3 left

One scored run a day; 31 days at least

Rules

  • One attempt: one scored attempt per day and only on one save file; after it, practice opens without points. A Daily can’t be continued: exiting ends the run DAILY.
  • Mods: the Daily won’t start with mods or the debug console enabled DAILYS-DCONS. If you installed EID for Tainted Cain, turn it off before the Daily.
  • Achievements and collection: only the mode’s own achievements work in the Daily ACH, and items picked up don’t go into the collection COLL.
  • R+ changes:
    • 1.9.7.6: own Daily seeds N-976.
    • 1.9.7.9: win streak counter, public and friend lobbies for the Daily N-979.
    • 1.9.7.10: force quit resets the streak N-9710.
    • 1.9.7.11: exiting practice no longer resets the streak N-9711.
  • Rotation since 1.9.7.11 N-9711:
    DayDaily
    MonMother
    TueTainted
    WedDelirium; since 1.9.7.13 random goal and character N-9713
    ThuHome (Beast)
    FriHard
    SatGrab Bag: random character, goal and difficulty
    SunMega Satan
  • Beast Daily: no trophy; the results screen appears by itself DAILY. Whether such a win counts toward Broken Modem is unconfirmed.

Tactics (safe-win protocol)

  • Before each scored attempt, read the day’s goal and character. Until you have The Marathon, play every Daily seriously. The most awkward days of the week (for example, Tuesday with Tainted) can be skipped: skipping doesn’t break the streak CARGO1.
  • After the streak, 2 more trophies give Broken Modem (wins from the streak count toward the 7). After that a quick death each day is enough for Dedication.
  • Don’t close the game with Alt+F4: force quit resets the streak N-9710.
  • Practice after your attempt doesn’t affect the streak; it’s handy for scouting the seed N-9711.

Online

3 left

Solo from your own lobby

Rules

  • Modes: R+ online is installed as a separate free DLC (since 18.11.2024). Up to 4 players: Friend Match, Public Match, Quick Match. All modes, challenges and the Daily are available RPSTOREN-RP.
  • Save risk: online is still in beta; the wiki warns: “can sometimes corrupt your save data” ONLINE. On 07.10.2026 someone on Steam complained about a save “wiped” after online play; it was restored from a backup S-WIPE. Back up before playing online.
  • Before playing: turn off mods and restart the game N-RP.
  • Restrictions: a player who joins a run already in progress gets no achievements ACHN-RP. The run uses the save of the player with the fewest unlocks ONLINE.
  • Crossplay Steam/Epic since 1.9.7.16 is enabled with the EosCrossplay line in options.ini N-9716.

Online achievements can be earned solo S-SOLO

  • An answer on Steam (October 2026): “You do not even need other players, but you must start it from a lobby (solo daily runs won’t work for that achievement)”.
  • Order: back up the save → mods off → your own lobby → Multiplayer Daily alone first → check Steam. If Play Online and Win Online dropped too, no regular online run is needed; otherwise one short lobby run to the nearest ending. This is a community-confirmed method, not a wiki-documented mechanic.
  • Win Online Daily: Daily → Multiplayer → create a lobby → start alone → kill the day’s goal. “Ending the run by killing its objective is enough” S-SOLO.
  • Play Online and Win Online: the same, from a lobby, a regular run until a win. Whether one win in a Multiplayer Daily awards all three at once is unconfirmed.
  • If an achievement doesn’t show up on Steam, open Main menu → Stats → Secrets: this pushes it through (Steam, December 2024) S-SECRETS.
  • For Dead God in R+ the online achievements are mandatory: “including 4 Repentance+ achievements” CARGO4.

From Russia

  • I found no public reports of R+ online being blocked (unconfirmed).
  • A Russian-language thread (February 2025) names the causes of lag: FPS below 60 for any player, high ping and “block circumvention tools (such as Zapret, GoodbyeDPI)” S-RU.
  • A solo lobby removes the matchmaking question.
  • You can find a partner on the official Discord (community-run, developer-supported) DISCORD or via Quick/Public Match.

In-run

4 left

Regular characters, any run

Order

  1. The streak for 5 Nights at Mom’s comes first: five quick wins, one of them Azazel → The Lamb under 20:00 for ZIP!. Marbles and Huge Growth count only if the combination is already there; never sacrifice the streak for them.
  2. After the streak: targeted Greed resets as Lazarus for Marbles (starting Gulp!) and Huge Growth (starting One makes you larger) S-GULP1S-HG22.
  3. Marbles unlocks Pica Run CARGO1TIPS: play it right after.

ZIP! and It’s the Key don’t interfere with each other: in 2018 a player going for It’s the Key as Azazel got ZIP! along the way S-ZIPKEY. These achievements don’t drop in challenges or the Daily CHACH.

Challenges

5 left

Five challenges and the Pica Run unlock

General rules. Only a challenge’s own achievements work inside it. Items tagged nochallenge are excluded: Lazarus’ Rags, Judas’ Shadow, Ankh, Clicker, R Key, and in R+ also Broken Ankh, Missing Poster and Mysterious Paper CH.

Challenge facts in the cards (start, goal, reward): CARGO1BRAINSPICAHOTREDDTTMT. DELETE THIS appears in the menu as an unnamed, unnumbered entry below the challenge list DT. You should already have all five unlocked, except Pica Run: it is waiting for Marbles.

Final

2 left

Death Certificate, then Dead God closes the set

Tainted ???

2 left

Tainted order 1 of 6 · 3 runs

Play it on Hard: a Hard mark also sets Normal and counts toward Death Certificate.

Basics for every mark

  • Do not hoard poops: they refill quickly in boss fights. wiki

Runs

The template runs that still give an unlock here; timers and portals are in Reference.

  1. Run A: Cathedral1 left
  2. Run C: Mother1 left

Reddit tips for every mark

  • Create creep near the edge of a boss arena and stand in it for fire-rate and damage bonuses; combining white poop with creep grants a particularly strong damage, fire-rate, and homing zone. Reddit community
  • Do not mix fart/green clouds with fire poop or fiery effects while standing nearby, because the resulting explosion can hurt you. Reddit community

Why here: Only three unlocks missing: three runs clear three goals

Mechanics TBB

  • Start: 3 soul hearts, 3 poops, the Hold active; tears −0.35, speed 0.90.
  • Poop pickups instead of bombs: a small one gives 1 poop, a large one 3. They drop from enemies and with a chance per damage dealt. Limit 10 (9 in the counter and 1 in Hold), 29 with Birthright TBBBRT.
  • Hold takes the leftmost poop; pressing again places or throws it. A thrown poop hits for 15; Stone hits up to three times.
  • Poop types:
    • Corn: blue flies.
    • Flaming: fire for 5 s.
    • Stinky: gas for 10.5 damage per second, explodes from fire.
    • Black: slowing creep, 10 damage and confusion when destroyed.
    • White: Hallowed Ground aura.
    • Stone: durable.
    • Bomb: explodes after 1.5 s.
    • Fart: 5 damage, poison, knockback.
    • Explosive Diarrhea: 5 live bombs.
    • Brown creep: 1.5× damage per tick to enemies, +1 dmg and +1.5 tears to Tainted ??? himself.
  • The Hallowed Ground aura gives fire rate ×2.5, a 50% chance to ignore damage, +20% damage and homing HGA.
  • Health is soul and black only. A devil deal costs 3 soul hearts; he doesn’t have regular ???’s discount DEVIL.
  • In R+ 1.9.7.11 the Bombs Are Key pill swaps poops and keys V1711.

Take TBB

  • Items: Rock Bottom, Dirty Mind, Mom’s Bracelet, Remote Detonator, Tech.5, The Candle / Red Candle (ignite gas from a distance), Gnawed Leaf, D20, homing.
  • Trinkets: Petrified Poop, Burnt Penny, Butt Penny, Lost Cork, Gigante Bean, Lil Larva.
  • Tinted rocks and secret rooms without bomb poops: Bob’s Rotten Head, Mr. Boom, Notched Axe.

Avoid TBB

  • Break your own poops: Marked, Tiny Planet, Mom’s Eye, Finger!, Holy Water, Book of Virtues.
  • Ignite gas: Bird’s Eye, Ghost Pepper.
  • Other: Blood Donation Machine, Devil Beggar, Guppy’s Paw, Judas’ Tongue, Little C.H.A.D.

Tactics

  • Don’t hoard poops: in boss fights they come back quickly. Save White and creep for hard fights, keep a bomb poop in Hold for secret rooms TBB.
  • White Poop in Hold on a boss gives ×2.5 fire rate and a 50% chance to take no damage (my conclusion from TBBHGA).
  • Tips from Steam (2021, before R+): keep Explosive Diarrhea or bomb for bosses; a thrown Stone hits for about 45. Fire next to Stinky gas causes an explosion of about 15 damage that hits you too S-TBB1S-TBB2.
  • Isaac doesn’t attack until he’s hit, so open the fight with a burst. In phase 3 he strikes with beams after every 200 damage taken; a shadow shows where they’ll land ISAACB.
  • ??? fires homing projectiles and teleports in front of you in phase 3. Don’t stand still BBB.
  • The Lamb detaches its body at 50% HP, and the body stays in place LAMB. This is a convenient target for Stinky and Black (my conclusion).
  • Hush: 6666 HP, regenerates if not hit for a long time. Don’t use I’m Drowsy against him HUSH.
  • Mother: in phase 1 she hangs at the top wall; Fistula after 6 bounces hits her. In phase 2 the head moves: spinning volleys, inhale, dashes MOTHER.
  • Runs: A (Cathedral: Heart, Boss Rush, Hush, Isaac, ???), B (Sheol: Satan, Lamb), C (Mother).

Tainted Forgotten

7 left

Tainted order 2 of 6 · 5 runs

Play it on Hard: a Hard mark also sets Normal and counts toward Death Certificate.

Basics for every mark

  • Keep the body between the Soul and the boss: it blocks projectiles and only the Soul takes damage. wiki
  • A thrown body deals 3× damage on hit plus 5 on landing; damage and speed are the key stats. wiki
  • Holy Mantle and Book of Shadows protect the Soul; avoid fear items (Mom’s Perfume, 2Spooky) and Mom’s Hands. wiki
  • Gnawed Leaf makes the Soul invulnerable while not attacking. wiki
  • Recall makes the body hit for 4-6× on return and the Soul is invulnerable meanwhile. wiki

Runs

The template runs that still give an unlock here; timers and portals are in Reference.

  1. Run A: Cathedral4 left
  2. Run B: Sheol1 left
  3. Run C: Mother1 left
  4. Run D: Beast1 left
  5. Run E: Greed1 left

Reddit tips for every mark

  • Use the thrown skeleton to press hazardous buttons or reach pickups, and prioritize familiars such as Seraphim, Lil Steven, or C Section because they fire from the skeleton’s position. Reddit community

Why here: In 2021 he was called fun and not counted among the worst S-WORST21

Mechanics TF

  • The body is invulnerable, hits for 3.5 × 1.5, tears × ½, and doesn’t walk on its own. Tainted Soul: 3 soul hearts, speed 1.0, doesn’t attack on its own. Health is shared, soul hearts only.
  • Only the Soul takes damage, and enemies target it. The body blocks projectiles and enemy movement.
  • The body on the floor swings a bone; holding the button charges a bone throw. The Soul picks up the body and throws it: the throw hit deals ×3 damage, the landing another 5.
  • The main stat is damage. Speed helps the Soul pick up the body; tears and range are less useful than usual.
  • A body thrown into a door enters the room, the Curse Room without damage. It buys whatever it is thrown into.
  • The Soul without the body opens the Mausoleum/Gehenna door without losing HP and passes the Downpour/Dross II mirror TF. Free Devil deals “as the Soul” were patched in 1.9.7.14 V1714.
  • Birthright gives Recall with a 3 s cooldown. On return the body hits for ×4-6, and the Soul is invulnerable during that time RECALL.

Take

  • Damage and speed.
  • Swing radius: size-up, Chocolate Milk, Mutant Spider, Technology.
  • Haemolacria, Monstrance, 120 Volt TF.
  • Holy Mantle and Book of Shadows: they work on the Soul TF.
  • Kamikaze!: a 185 explosion at the body, unlimited, safe if the Soul is outside the radius. In R+ it’s also in Greed Treasure KAMI.
  • Gnawed Leaf: the Soul is invulnerable while you’re not attacking; walking doesn’t break it GL.

Avoid: fear (Mom’s Perfume, 2Spooky), Damocles, Lost Soul, Pluto, Size Down. Mom’s Hands drag the body away TF.

Bosses

  • General cycle: keep the body between the Soul and the boss, throw, pick up or Recall, throw again. Explosions at the body bypass armor, which is especially valuable against Mother and Hush DS.
  • Beast: in this fight the body flies and hangs where it was thrown. Recall is especially needed here BEAST.
  • Delirium: hit the main form. Polyphemus, Saturnus, freezing and Kamikaze! help S-DEL21.
  • Hush + Boss Rush: Stop Watch, orbitals, body as a shield HUSH. The wiki’s bug note: Stop Watch and I’m Drowsy make Hush’s final-phase lasers impossible to outrun, so finish him fast once he is below 20% HUSH.
  • Mother: the Soul without the body passes the mirror for Knife Piece 1 and the Mausoleum door without damage TF.
  • Ultra Greedier: the body blocks Ultra Greed’s coins, and they explode at it S-UG21. The Soul presses the button in Greed without damage at the cost of a coin TF.

Mistakes: throwing the body into price tags; throwing it far when the Soul is surrounded; taking fear items TF.

Videos: Beast in R+, Mother

Tainted Eden

2 left

Tainted order 3 of 6 · 2 runs

Play it on Hard: a Hard mark also sets Normal and counts toward Death Certificate.

Basics for every mark

  • Put needed cards and pills on the floor so a hit does not reroll them; carry any trinket for a chance at Cancer or Cracked Crown. wiki
  • Damocles is not rerolled and doubles items; Holy Mantle and Blanket cancel rerolls. wiki
  • With We Need To Go Deeper! or Red Key, open crawl spaces or Ultra Secret Rooms right away before a hit rerolls the item. wiki

Runs

The template runs that still give an unlock here; timers and portals are in Reference.

  1. Run C: Mother1 left
  2. Run D: Beast1 left

Reddit tips for every mark

  • Leave Treasure, Shop, and other pedestal items uncollected until after the boss/Deal spawns; then collect them so future damage rerolls use the last spawned pool, potentially turning them into Deal items. Reddit community
  • Avoid Red Chest pool items when possible because a reroll into Dead Cat can abruptly reduce your health to one container. Reddit community

Why here: Unpredictable: “the Delirium of playable characters” S-EDENT; Beast last

Mechanics TE

  • Start: random health, stats, active and passive.
  • Any damage except self-damage rerolls all stats, passives, the active, the trinket and the card or pill in hand.
  • Not rerolled: Polaroid, Negative, Dad’s Note, Damocles, Dogma, Key Pieces, Knife Pieces. Swallowed trinkets stay; a second trinket drops to the floor on hit.
  • The reroll is seeded. Glowing Hourglass in the same room rolls the build back, but a repeated hit gives the same result.
  • Rerolls are not triggered by TEV175:
    • self-damage: Blood Donation, Devil Beggar, Curse Room doors;
    • a fatal hit (since 1.7.5) and a fatal hit with a revive item;
    • a Holy Mantle trigger; Blanket works the same way, but only in boss fights.
  • A reroll easily takes away health and doesn’t give it back. Keep 6-9 hearts, leave some on the floor. HP from pills, Converter and Eternal Hearts stays permanently TE.
  • Birthright: items taken before it are no longer rerolled. It protects the active until it’s replaced. Only in the Shop and Greed Shop pools TEBRT.

Take TE

  • Item count; the best pools are Angel and Planetarium.
  • Carry any trinket: it’s a chance at Cancer or Cracked Crown. Put cards and pills you need on the floor.
  • Helpful: Holy Mantle, Blanket, Death Certificate, Smelter/Gulp!, Converter/Empty Heart, PHD, NO! (the active rerolls into a passive), Book of Virtues from the Library.
  • Per-floor effects: Black Candle, Treasure Map, Compass, Blue Map, The Mind.
  • Damocles is not rerolled and doubles items. After the first hit the sword falls with a 1/10000 chance every 4 ticks DAMO, on average after roughly 22 minutes by my calculation.

Avoid: Missing No., TMTRAINER, Bloody Lust, Magic Skin TE. Devil and Curse: on Steam people write that Dead Cat after Mom is nearly a death sentence S-EDEN.

Tactics

  • Only an enemy hit triggers a reroll. A tip from Steam: collect several Angel items and take a hit to roll Holy Mantle S-EDEN.
  • With We Need To Go Deeper! or Red Key, open a Crawl Space or Ultra Secret right away, before the item gets rerolled TE.
  • The tip “craft 10 Eden’s Blessing with Tainted Cain” is outdated: in R+ 1.9.7.9 the limit was lowered to 2 items S-EBEBLESS.

Bosses

  • Beast do last: after the TMTRAINER unlock it can appear on reroll TE.
  • Mother: Knife Pieces are not rerolled TE.

Tainted Lazarus

7 left

Tainted order 4 of 6 · 5 runs

Play it on Hard: a Hard mark also sets Normal and counts toward Death Certificate.

Basics for every mark

  • Use Flip on room-generated pedestals: buying the real item in a Shop or Devil Room also pays for its ghost, which you take after flipping. wiki
  • Don’t pour all damage into one form: give the living form Cricket’s Head or Synthoil early, and spread The Body and Cancer across both forms. wiki
  • Boss drops, chests and beggars have no ghost items. wiki
  • Only enter the boss with Flip charged: in a fight it works like a second health bar. community
  • Leave uncleared rooms nearby to recharge Flip before the boss (Steam, 2021-2022). community
  • Trap: if a form hits zero during the Flip animation you continue as the other form but die when switching back. wiki
  • Birthright makes the inactive form an invulnerable ghost dealing 25% damage and gives actives double charge per clear. wiki

Runs

The template runs that still give an unlock here; timers and portals are in Reference.

  1. Run A: Cathedral4 left
  2. Run B: Sheol1 left
  3. Run C: Mother1 left
  4. Run D: Beast1 left
  5. Run E: Greed1 left

Reddit tips for every mark

  • Build Dead Lazarus as the boss killer because of his 1.5× damage multiplier; give Living Lazarus defense, health, familiars, and bomb damage. Reddit community
  • Enter a boss as the weaker form and use Flip during the fight so the stronger form gets the long damage window; enter Deals with Flip charged. Reddit community

Why here: October 2025: “no longer that awful, but meh”, easier than Tainted Jacob and Tainted Cain S-HARD25. Flip early helps the collection

Mechanics TLFLIP

  • Living form: 3 red hearts, range 4.50. Dead Tainted Lazarus: 2 soul hearts, damage ×1.5, tears −0.1, speed 0.90, range 6.50, luck −2.
  • The form switches after every room clear, including Challenge Room, Boss Rush and Greed waves. Flip in the pocket slot switches it instantly. In R+ it has 4 charges, 6 for other characters FLIP.
  • Items generated with the room have a “ghost”, and Flip swaps the real item and the ghost. Buying the real item in a Shop or Devil Room also pays for the ghost, which you can take after Flip. Boss drops, chests and beggars have no ghosts FLIP.
  • The forms have separate items, stats, trinkets and consumables; actives charge for both. Shared between forms: quest items, Polaroid/Negative, Key/Knife Pieces, deal chance. An extra life revives only the form that picked it up TL.
  • Trap: if a form hits zero during the Flip animation, you live on as the other form but die when switching back TL.
  • Birthright: the inactive form walks alongside as an invulnerable ghost and deals 25% damage. Actives get a double charge per clear BRTTL.

Take TL

  • Cricket’s Head or Synthoil for the living form as early as possible.
  • Distribute The Body and Cancer between forms.
  • Chaos, Diplopia, Crooked Penny, Star of Bethlehem, Sharp Straw, Glass Cannon.
  • Red Key, The Battery, Jumper Cables (Flip charges).

Careful: extra lives, Blood Puppy, 4.5 Volt TL. The Quints trick in Greed was fixed in 1.9.7.11 V1711.

Bosses

  • Before a boss, keep Flip charged and leave uncleared rooms nearby for recharging (Steam, 2021-2022) S-TL21S-TL22. In a fight, Flip works like a second HP bar.
  • Beast: the form switches after each boss, including the Ultra Harbingers. Both forms get Dogma’s flight and stats; healing and Holy Mantle only the active one TL. In R+ the Beast’s phase 1-2 attacks are shuffled BEAST.
  • Boss Rush: the form switches on every wave TL.
  • Greedier: the form switches after every wave, and you lose control for about 1 s. The ghost with Birthright presses the button without damage TL.
  • Delirium: hit the main form, it has no armor DELDS.

Mistakes: putting all damage into the dead form while the living one lags behind; forgetting ghosts in the Shop and Devil Room; entering a boss fight with Flip empty TL. A recent assessment from Steam: “just kinda bad”, but Birthright helps a lot S-DIFF.

Videos: jam guide (pre-R+), Greedier in R+

Tainted Cain

7 left

Tainted order 5 of 6 · 5 runs · Run B early, with It’s the Key

Play it on Hard: a Hard mark also sets Normal and counts toward Death Certificate.

Basics for every mark

  • Use the EID mod’s recipe list for the current seed; mods do not disable achievements once Mom has been killed on the save. Disable it before Dailies and online. wiki
  • For quality-4 items from regular pools aim for a crafting sum of 35+ (e.g. 4 Soul Hearts + 4 Dimes/Charged Keys); keep coins for the shop. wiki
  • Recipes depend on the seed since 1.7.5; an 8-item recipe for a locked item gives a random item. wiki

Runs

The template runs that still give an unlock here; timers and portals are in Reference.

  1. Run A: Cathedral4 left
  2. Run B: Sheol2 left
  3. Run C: Mother1 left
  4. Run D: Beast1 left
  5. Run E: Greed1 left

Reddit tips for every mark

  • Finish the floor before crafting: leave pickups down until you know the full supply, then test cheap recipes such as 5-7 pennies plus common pickups instead of waiting only for premium materials. Reddit community
  • Items broken in a Secret Room are more likely to yield Bone Hearts, while Angel- and Devil-room items supply Eternal or Black Hearts for higher-value crafting. Reddit community

Why here: Run B goes early, together with It’s the Key. The other four runs come here: with EID “basically impossible to lose” S-TCEID, without EID hard and “looong and boring” S-HARD25; crafting power in R+ depends on the seed and EID

Unlocks: Gilded Key, Lucky Sack, Blue Key, Bag of Crafting, Gold Pill, Soul of Cain, X - Wheel of Fortune? TC. The Delirium unlock makes Bag of Crafting start appearing for all characters V175.

Mechanics

  • Start: 2 red containers, 1 key, Bag of Crafting in the pocket slot. Since 1.7.9b, stats are the same as Cain’s TCV179b.
  • On touch, a pedestal breaks into pickups. Their type depends on the room: Secret gives Bone Hearts, Curse gives Rotten, Planetarium gives Runes, Devil gives Black, Angel gives Eternal, Ultra Secret gives Cracked Keys. Story items (Polaroid, Negative, Key/Knife Pieces, Dad’s Note) are picked up as usual TC. How many pickups a pedestal gives is unconfirmed.
  • The bag: a swing hits for 3 and picks up pickups behind rocks and pits. It has 8 slots, holding the Pill/Card button crafts. Switch shifts the contents, a ninth pickup pushes out the top-left one, and pickup order doesn’t matter BOC.
  • The result depends only on the 8 components and the run seed; room and floor have no effect EIDCS-CRAFT. Since 1.7.5 almost all recipes depend on the seed, and a recipe for a locked item gives a random item V175.
  • Birthright doubles the pickups from a pedestal. It is only in the Shop pool TCBRT.

Pickup Values BOC

ValuePickups
0Poop Nugget
1Penny, Red Heart (and half), Rotten Heart
2Bomb, Key, Cracked Key, Card, Pill, Micro Battery
3Nickel
4Soul Heart, Rune/Soul Stone, Dice Shard, Lil’ Battery
5Black, Bone, Eternal, Gold Heart; Charged Key; Dime
7Golden Penny, Key, Bomb, Pill, Battery
8Lucky Penny, Mega Battery
10Giga Bomb

Sum → Item Quality BOC

Regular PoolsDevil/Angel/SecretQuality
0-80-130-1
9-1414-190-2
15-1820-231-2
19-2224-272-3
23-2628-312-4
27-3432-393-4
35+40+4

Pool selection. Base weights: Treasure 1×, Shop 2×, Boss 2×. Components add weight to their pools: Black Heart gives Devil 10×, Eternal gives Angel 10×, Bone gives Secret 5×, Gold Heart gives Golden Chest 10×, Rotten gives Curse 10×, Cracked Key gives Red Chest 10×, Poop gives Shell Game 10×. If Devil, Angel or Secret is rolled, 5 is subtracted from the sum BOC.

Fixed recipes (identical on any seed) BOC

  • 8 Eternal Heart → Sacred Heart; Gold Heart + Soul Heart + Red Heart + 5 Eternal Heart → Godhead
  • 8 Black Heart → Brimstone; 8 Soul Heart → Soul Locket; 8 Red Heart → Yum Heart; 2 Rotten + 6 Red Heart → Yuck Heart
  • 2 Golden Key + 6 Key → Dad’s Key; 8 Key → Latch Key; 8 Cracked Key → Red Key
  • 8 Giga Bomb or 2 Golden Bomb + 6 Bomb → Mama Mega!; 8 Bomb → Mr. Mega (in R+; previously Mr. Boom)
  • 8 Card → Deck of Cards; 8 Pill → PHD; Black Heart + 7 Pill → False PHD
  • 8 Penny → Portable Slot; 8 Dice Shard → D infinity; 8 Poop Nugget → The Poop
  • 8 Bone Heart → Death Certificate. Until the Death Certificate achievement is unlocked, a random item drops instead V175.

How to craft in practice

  • Install the External Item Descriptions (EID) mod. It shows the recipe list for the current seed and a preview of the result; Right Shift opens search EIDEIDCFG. On Steam people write: “T Cain is probably the strongest Character when Recipe List is turned on” S-TCEID. Mods do not disable achievements if Mom has already been killed on the save ACH. Turn mods off before the Daily and online play DAILYN-RP.
  • For Q4 in regular pools you need a sum of 35 or more. For example, 4 Soul Heart + 4 Dime or Charged Key give 36 (my calculation from the table). Black, Eternal and Bone pull toward a special pool, which needs 40 or more.
  • Don’t throw coins and red hearts into the bag right away; that gives low quality. Hoard, swap cheap for expensive, and leave pedestals for later until you’ve stockpiled material TC. Coins are better spent in the shop S-TCEID. For expensive recipes, top up with batteries, cards and pills S-FILL.
  • Since 1.7.5, shop pickups can be bought with a bag swing V175.
  • The west-games calculator only estimates quality and pool; it doesn’t name a specific item WEST.

Take: Birthright, Sack Head, Mitre, Black Lipstick / Mom’s Pearl / Bible Tract, D20, Everything Jar, Moving Box, Abyss / Void / Black Rune, Portable Slot, Death Certificate (items in its room are picked up whole) TC.

Avoid: Magneto, range ups (especially Tiny Planet), Humble Bundle / BOGO Bombs, Bum Friend / Dark Bum / Key Bum / Bumbo, Magic Skin, Little Baggy / Starter Deck TC.

Bosses

  • Hush + Boss Rush: if you missed the timer, craft Mama Mega! (fixed recipe) or Mega Bean (R+, Q1, Treasure pool). The wiki calls Mega Bean “much cheaper to craft” TCMBEAN.
  • Mega Satan: Dad’s Key (2 Golden Key + 6 Key), used in the starting room, opens the door MS.
  • Delirium: no armor in the main form. Stop Watch, I’m Drowsy help, and in R+ also Broken Modem DEL.
  • Mother: received armor in R+ V1974. Gnawed Leaf stops her dashes in the second phase MOTHER.
  • Beast: always the last run, because the fight ends the run TC.
  • Ultra Greedier: shops in Greed restock, and Birthright with repeated discounted item purchases gives “almost infinite consumables” TCGREED. Items tagged nogreed can’t be crafted BOC. Plan C counts for the mark PLANC.

Common mistakes

  • Using recipes from guides older than November 2021: since 1.7.5 recipes depend on the seed V175.
  • Breaking down actives in the Secret Room for Bone Hearts: since 1.7.9b this doesn’t work V179b.
  • Overwriting a nearly complete bag with an extra pickup BOC.

R+ 1.9.7.13 fixed a bug that made rerolls turn crafted items into Breakfast V1713.

Tainted Jacob

7 left

Tainted order 6 of 6 · 5 runs

Play it on Hard: a Hard mark also sets Normal and counts toward Death Certificate.

Basics for every mark

  • Aim Esau: chain him with Anima Sola, stand so the boss is between you on one line, press again, then step off the line. wiki
  • Dark Esau only dashes along horizontal or vertical lines; stay diagonal from him. wiki
  • Esau’s dash ignores boss armor and early bosses die in one or two dashes. wiki
  • Shields and invulnerability block Esau’s touch; 9 Volt, The Battery and Car Battery speed up Anima Sola. wiki
  • Avoid Book of Virtues, Isaac’s Heart, Lost Soul and Epiphora on Tainted Jacob. wiki

Runs

The template runs that still give an unlock here; timers and portals are in Reference.

  1. Run A: Cathedral4 left
  2. Run B: Sheol1 left
  3. Run C: Mother1 left
  4. Run D: Beast1 left
  5. Run E: Greed1 left

Reddit tips for every mark

  • Use Dark Esau offensively: chain him while he overlaps a stationary boss, then reactivate Anima Sola to release an immediate high-damage charge. Reddit community
  • Force Dark Esau to spawn in an empty room with Anima Sola at the start of a floor so he does not appear unexpectedly during combat. Reddit community

Why here: Consistently the hardest: 2021, January 2024, October 2025 S-HARD21S-TJ24S-HARD25

Mechanics TJAS

  • Start: 3 red containers, tears +0.277, Anima Sola in the pocket slot.
  • Anima Sola holds Esau on a chain for 5 s, cooldown 15 s. Pressing again releases him, and Esau dashes toward Jacob, burning everyone in his path. While chained he deals no contact damage; in an empty room Anima Sola summons him immediately AS.
  • Dark Esau appears 20-40 s after entering a floor and has been invulnerable since 1.7.5 TJV175:
    • he only dashes if you’re on his horizontal or vertical line; he doesn’t attack diagonally;
    • his position is tied to the floor layout; entering a new room cancels a dash windup;
    • he blocks enemy projectiles.
  • Esau’s damage: contact about 60 DPS, dash about 300 DPS plus Burning. The dash ignores boss armor TJDS.
  • After Esau’s touch, Jacob becomes The Lost without Holy Mantle until the next floor. Devil deals are free then, one per room in R+. Shields and invulnerability block the touch TJLOST.
  • Birthright: two Esaus dash at once, cooldown 10 s. Only since 1.9.7.13 does the second Esau actually hurt Jacob, so old advice about a “safe Birthright” is outdated ASV1713.

How to aim Esau ASTJ

  1. Catch him with Anima Sola.
  2. Stand so that the boss is between you on one line.
  3. Press Anima Sola again.
  4. Immediately get off the line.

Early bosses die in one or two dashes.

Take TJ

  • Anima Sola charge: 9 Volt, The Battery, Car Battery.
  • Defense: Gnawed Leaf, Holy Mantle, Book of Shadows, Unicorn Stump, Stop Watch, Pause, Punching Bag.
  • Glowing Hourglass: returns the living form in that room.
  • Mobility: How to Jump, Ventricle Razor, flight.
  • Satanic Bible or Devil’s Crown: to become the Lost on purpose for free deals.

Avoid TJ: Book of Virtues, Isaac’s Heart, Lost Soul, Dead Cat in Lost form, Epiphora, Vasculitis. Tips about killing Esau with Eraser, Meat Cleaver or exiting to the menu are outdated since 1.7.5 S-TJ21b.

Bosses

  • Dash targets: armored bosses are best: Mother, Hush, Mega Satan, Delirium in another boss’s form, Ultra Greedier DS.
  • Mother: in the Mines, touch Esau on purpose and escape Mother’s Shadow with Knife Piece 2 using the Lost form’s flight TJ.
  • Beast: Esau kills Ascent mobs instantly S-TJ24. Dogma gives a one-time Holy Mantle, and the mantle absorbs Esau’s touch BEASTTJ.
  • Hush + Boss Rush: build like the Lost: shields such as Book of Shadows, and damage (Steam, 2021; that tip also named Mega Mush, an old optional example) S-TJBR21.
  • Ultra Greedier: Anima Sola recharges at the start of each wave TJ.
  • Deals: after a boss, touch Esau on purpose and take one free Devil item; HP is preserved (Steam, January 2024) S-TJ24.

Mistakes: standing on Esau’s line; moving to an adjacent room when he’s nearby; releasing the chain without an escape route.

Videos: video 1, video 2

Achievements

Every achievement still missing: what it gives (for a trinket, what it does) and how to get it. Tap a name for tips and the route.

  1. Dedication #325

    Gives Pill Horf! Pill effect: fires one explosive Ipecac-style tear that always deals 200 damage. The horse version fires a cluster of 6 Horf! tears dealing 150-400 each.
    How Take part in 31 Daily Challenges. They need not be consecutive, and dying in the first room still counts.

  2. Broken Modem #354

    Gives Item Q3 Broken Modem Enemies, shots, tears and pickups randomly freeze for a moment (more often with higher Luck). Room-clear rewards have a 25% chance to duplicate, except chests, pills and cards.
    How Complete 7 Daily Challenges by reaching the goal and touching the trophy at the end.

  3. The Marathon #336

    Gives Trinket Cracked Crown In Repentance it boosts every stat that is above base by 20% of the bonus (40% when golden or with Mom’s Box). Luck is not affected, and it does nothing for stats at or below base.
    How Get a 5-win streak in the Daily Challenges. Days need not be consecutive; only Dailies you actually play count.

  4. Play Online #638

    Gives No item. Achievement only (Repentance+). Required for Dead God in Repentance+.
    How Play an online game (Repentance+ online multiplayer).

  5. Win Online #639

    Gives No item. Achievement only (Repentance+). Required for Dead God in Repentance+.
    How Win an online run (Repentance+ online).

  6. Win Online Daily #640

    Gives No item. Achievement only (Repentance+). Required for Dead God in Repentance+.
    How Win an online Daily run (Repentance+).

  7. Marbles #386

    Gives Item Q2 Marbles Spawns 3 random trinkets. Taking damage has a small chance (the wiki lists 5% and 10%) to swallow your held trinket permanently. Swallowed trinkets are safe from D4 and Tainted Eden rerolls.
    How Use 5 Gulp! pills in one run; Placebo uses of Gulp! count.

  8. Huge Growth #361

    Gives Card Huge Growth Special card: for the current room Isaac becomes much larger, crushes obstacles by walking over them, and gets +7 flat damage and +3 range. Multiple uses in one room do not stack.
    How Increase Isaac’s size 5 times in one run (fandom wording) via Magic Mushroom, ’One makes you larger’ pills, XI - Strength and similar. Current wiki.gg wording: become 3 times your starting size, about 5-7 size-ups.

  9. It’s the Key #327

    Gives Card Ace of Spades Turns all pickups, chests and (since Repentance) non-boss enemies in the room into random keys.
    How Defeat The Lamb without picking up any hearts, coins or bombs during the whole run. Familiars or bosses that collect them for you (Bum Friend, Dark Bum, Bumbo, Lil Portal, Bumbino) also fail it.

  10. 5 Nights at Mom’s #323

    Gives Unlock Super Special Rocks A rarer tinted-rock variant with smaller marks and no discoloration. It takes two bombs and drops the contents of two Tinted Rocks; only one can spawn per room.
    How Get a 5-win streak using a different character for each win. Repentance+ requires exactly 5 wins.

  11. Stud Finder #230

    Gives Trinket Stud Finder Each destroyed rock has an extra 1/200 chance to reveal a Crawl Space (1/100 when golden or with Mom’s Box).
    How Complete challenge #27 BRAINS! (??? blindfolded with 3× Bob’s Brain and Thunder Thighs, no Treasure Rooms; goal ???).

  12. Pica Run #512

    Gives Challenge Pica Run (challenge #41) Isaac starts with Mom’s Box, Marbles and Mom’s Purse (4 trinkets on the floor); every item pedestal becomes a trinket and Marbles swallows your trinket on every hit. Goal: Isaac; completing it unlocks Ice Cube.
    How Defeat Mom’s Heart 11 times and unlock Marbles.

  13. Ice Cube #522

    Gives Trinket Ice Cube On entering a room each enemy has a 20% chance (100% at 40 Luck) to be petrified for 4 s; enemies killed while petrified, or up to 2 s after, are frozen. Golden version or Mom’s Box adds nothing.
    How Complete challenge #41 Pica Run (goal: Isaac).

  14. The Chariot #531

    Gives Card VII - The Chariot? Reversed tarot: Isaac becomes an invincible statue with 4× fire rate for 10 s; it can be nudged slightly and is affected by knockback.
    How Complete challenge #42 Hot Potato (Tainted Forgotten, blindfolded, the body explodes every 2.5 s; goal Satan).

  15. Temperance #538

    Gives Card XIV - Temperance? Reversed tarot: forces Isaac to eat 5 random pills in quick succession.
    How Complete challenge #45 DELETE THIS (Isaac with TMTRAINER; goal ???). It appears as an unnamed entry below the challenge list.

  16. Death Certificate #636

    Gives Item Q4 Death Certificate Single-use active: takes you to an abandoned, expanded Home with one copy of every item you have unlocked; taking one returns you. The main tool for finishing the collection.
    How Earn every Hard-mode completion mark for all 34 characters, including Tainted ones (Mom’s Heart/It Lives, Isaac, ???, Satan, The Lamb, Boss Rush, Hush, Mega Satan, Delirium, Mother, The Beast, Ultra Greedier).

  17. Dead God #637

    Gives No item. Per the wiki, earning Dead God on all 3 save files gives a special graphic on the save-file select screen.
    How Unlock every other achievement (in Repentance+ including the R+ achievements such as the online ones) and collect every item on the collection page.

  18. Ring Cap #557

    Gives Trinket Ring Cap Every bomb you place spawns one extra free bomb next to it; opens the Mines door with a single bomb. No effect with Dr. Fetus, Epic Fetus or for Tainted ??? himself.
    How Defeat Mother as Tainted ???.

  19. Soul of ??? #622

    Gives Rune Soul of ??? Soul stone: 8 poison farts that leave brown creep, then a trail of 7 Butt Bombs. Standing in the creep gives +1.5 fire rate and +1 damage.
    How Defeat Hush and complete Boss Rush as Tainted ???.

  20. Polished Bone #576

    Gives Trinket Polished Bone After clearing a room, chance to spawn a friendly Bony or Black Bony (higher when golden or with Mom’s Box).
    How Defeat Isaac, ???, Satan and The Lamb as Tainted Forgotten (accumulates across runs).

  21. Hollow Heart #577

    Gives Trinket Hollow Heart Grants one empty Bone Heart each time you enter a new floor (2 when golden or with Mom’s Box), including each Ascent floor.
    How Defeat Mother as Tainted Forgotten.

  22. Isaac’s Tomb #505

    Gives Item Q2 Isaac’s Tomb Spawns an Old Chest at the start of each floor (needs a key): 1-3 Soul Hearts (43%), 3 trinkets (42%), an Old Chest item (10%) or an Angel item (5%).
    How Defeat The Beast as Tainted Forgotten.

  23. Decap Attack #598

    Gives Item Q1 Decap Attack Active (4 s recharge): throws Isaac’s head, which keeps firing tears where it lands, blocks shots and deals 24 impact + 12 DPS contact damage. The head is invulnerable; reuse or step on it to reattach.
    How Defeat Delirium as Tainted Forgotten.

  24. Golden Battery #615

    Gives Unlock Golden Battery Battery pickup variant: gives charges but deals a full heart of damage when picked up, and spawns another Golden Battery in a random room. Holy Mantle-type shields block the damage.
    How Defeat Mega Satan as Tainted Forgotten.

  25. Soul of the Forgotten #632

    Gives Rune Soul of the Forgotten Soul stone: spawns The Forgotten as a temporary second character for the room, controlled alongside Isaac; his bone swing hits hard and reflects shots.
    How Defeat Hush and complete Boss Rush as Tainted Forgotten.

  26. Death #537

    Gives Card XIII - Death? Reversed tarot: each enemy killed in the room spawns a friendly Bony or a temporary bone orbital.
    How Defeat Ultra Greedier as Tainted Forgotten.

  27. Modeling Clay #567

    Gives Trinket Modeling Clay On entering a room, 50% chance (100% golden/Mom’s Box) to mimic a random summonable passive item from that room’s pool.
    How Defeat Mother as Tainted Eden.

  28. TMTRAINER #500

    Gives Item Q0 TMTRAINER All items found after picking it up become glitched, with random combinations of effects. Quest items (Polaroid, Negative, Key/Knife Pieces, Dad’s Note) are unaffected.
    How Defeat The Beast as Tainted Eden.

  29. Torn Pocket #564

    Gives Trinket Torn Pocket When you take damage you drop 2 random pickups from your inventory (not hearts, pills or cards).
    How Defeat Isaac, ???, Satan and The Lamb as Tainted Lazarus (accumulates across runs).

  30. Torn Card #565

    Gives Trinket Torn Card Every 15 shots, Isaac fires an Ipecac + My Reflection tear that returns toward him and explodes. Pyromaniac or Host Hat remove the self-damage risk; homing reduces it.
    How Defeat Mother as Tainted Lazarus.

  31. Salvation #499

    Gives Item Q3 Salvation Gives a halo; enemies inside it are struck by beams of light (up to ~152 damage at the centre). The halo grows each time you are hurt on the floor (max 10) and resets on a new floor.
    How Defeat The Beast as Tainted Lazarus.

  32. Flip #592

    Gives Item Q4 Flip Active: room-generated pedestals show a ghost item; using Flip swaps real and ghost so both can be taken. Recharge 6 rooms (Tainted Lazarus uses it in 4 rooms in Repentance+ and also swaps forms).
    How Defeat Delirium as Tainted Lazarus.

  33. Wooden Chest #609

    Gives Unlock Wooden Chest Chest variant that can replace regular chests: 2 cards/runes (45%), 2-3 pills (45%) or a Wooden Chest pool item (10%).
    How Defeat Mega Satan as Tainted Lazarus.

  34. Soul of Lazarus #626

    Gives Rune Soul of Lazarus Soul stone: auto-used on fatal damage, reviving you at half a heart in the same room with some invincibility. It has the highest priority of all revives.
    How Defeat Hush and complete Boss Rush as Tainted Lazarus.

  35. Judgement #543

    Gives Card XX - Judgement? Reversed tarot: creates a Shop Restock Machine next to Isaac.
    How Defeat Ultra Greedier as Tainted Lazarus.

  36. Gilded Key #552

    Gives Trinket Gilded Key Replaces all new chests (except Mega and Old Chests) with golden chests, which then give an item (20%) or 2-6 pickups that can include cards, runes, trinkets and batteries. Gives 1 key on first pickup.
    How Defeat Isaac, ???, Satan and The Lamb as Tainted Cain (progress accumulates across runs).

  37. Lucky Sack #553

    Gives Trinket Lucky Sack Spawns a Grab Bag each time you go to a new floor; golden or Mom’s Box adds one more.
    How Defeat Mother as Tainted Cain.

  38. Blue Key #493

    Gives Trinket Blue Key Key-locked doors open without keys, but lead through a long ???-style in-between room with Blue Womb monsters. Door Stop or Mercurius lets you skip it.
    How Defeat The Beast as Tainted Cain.

  39. Bag of Crafting #586

    Gives Item Q3 Bag of Crafting Active (unlimited recharge): swing it to collect up to 8 pickups, then craft an item whose quality depends on the pickups’ values. The swing deals 3 damage and can buy shop pickups.
    How Defeat Delirium as Tainted Cain. Once unlocked, Bag of Crafting can appear for all characters.

  40. Gold Pill #603

    Gives Pill Gold Pill Gold pills give a random pill effect not in the run’s pill pool and only have a chance to be used up, so they can be used many times. PHD/Lucky Foot alter their effects; can also be a horse pill.
    How Defeat Mega Satan as Tainted Cain.

  41. Soul of Cain #620

    Gives Rune Soul of Cain Soul stone: opens all doors in the room and creates Red Rooms on all valid walls, like Red Key; also breaks the Downpour/Dross II mirror. It can open the Mega Satan door.
    How Defeat Hush and complete Boss Rush as Tainted Cain.

  42. Wheel of Fortune #534

    Gives Card X - Wheel of Fortune? Reversed tarot: triggers a random Dice Room effect.
    How Defeat Ultra Greedier as Tainted Cain.

  43. RC Remote #580

    Gives Trinket RC Remote Familiars stop trailing behind and move with Isaac’s own inputs; holding drop keeps them in place, like Jacob and Esau.
    How Defeat Isaac, ???, Satan and The Lamb as Tainted Jacob (accumulates across runs).

  44. Found Soul #581

    Gives Trinket Found Soul Spawns a flying ghost familiar that copies Isaac’s movement and fires spectral tears with half his damage. It dies when hit and returns next floor; can use a Devil Beggar or Blood Donation Machine once for free.
    How Defeat Mother as Tainted Jacob.

  45. Esau Jr. #507

    Gives Item Q1 Esau Jr. Active (1-room): swaps between you and Esau Jr. (3 black hearts, +2 flat damage, flight) with separate items and health; first use gives him random items matching yours. If either dies, the run ends.
    How Defeat The Beast as Tainted Jacob.

  46. Anima Sola #600

    Gives Item Q3 Anima Sola Active (15 s): chains the nearest enemy, even an invulnerable one, for 5 s; reuse to release early. Tainted Jacob starts with it to control Dark Esau.
    How Defeat Delirium as Tainted Jacob.

  47. Golden Trinket #617

    Gives Unlock Golden Trinkets Any trinket can spawn golden (2%), doubling its effect like Mom’s Box (3× with Mom’s Box). Some golden trinkets gain special effects.
    How Defeat Mega Satan as Tainted Jacob.

  48. Soul of Jacob and Esau #634

    Gives Rune Soul of Jacob and Esau Soul stone: spawns Esau as a temporary second character for the room with random items equal in number to yours.
    How Defeat Hush and complete Boss Rush as Tainted Jacob.

  49. The Sun and the Moon #542

    Gives Card XVIII - The Moon? and XIX - The Sun? Reversed Moon teleports you to the Ultra Secret Room with a Red Room path back. Reversed Sun grants Spirit of the Night and +1.5 damage for the floor, temporarily converts red hearts to bone hearts and causes darkness.
    How Defeat Ultra Greedier as Tainted Jacob.

Rewards

How much each unlock helps future runs, 0-10 (my estimate from the wiki effects and item quality); ties go to the more common achievement. ★ is difficulty. Use it when two goals cost about the same.

  1. S Must-have 9-10
  2. 9Flip T. Lazarus item Q4Take both items from every room pedestal. Huge value for everyone.
  3. 9Death Certificate Final item Q4Once per run, pick any unlocked item from the item room. Run-defining.
  4. A Strong 7-8
  5. 8Bag of Crafting T. Cain item Q3Craft items from pickups; strong once you learn recipes.
  6. 8Gold Pill T. Cain pillEffects outside the run’s pill pool, often not consumed. Repeatable value.
  7. 8Soul of Cain T. Cain runeFree Red Key effect on every wall, opens Ultra Secret routes.
  8. 8Soul of Lazarus T. Lazarus runeAn extra life on fatal damage.
  9. 7Broken Modem Daily item Q3Frequent freezes and doubled room rewards. Q3.
  10. 7Anima Sola T. Jacob item Q3Lock any enemy, even invulnerable ones, for 5 s. Great on bosses.
  11. 7Salvation T. Lazarus item Q3Damage halo that grows over the floor. Solid Q3.
  12. B Good 5-6
  13. 6Gilded Key T. Cain trinketGolden chests everywhere, items and lots of coins.
  14. 6The Marathon Daily, Cracked Crown trinket+20% to all stats above base. Scales with strong builds.
  15. 6Golden Trinket T. Jacob, Golden Trinkets unlock2% of trinkets spawn golden with doubled effects.
  16. 5Marbles In-run item Q23 trinkets now; can eat trinkets for permanent effects.
  17. 5Soul of the Forgotten T. Forgotten runeTemporary second character for the room.
  18. 5Lucky Sack T. Cain trinketA Grab Bag every floor.
  19. 5Isaac’s Tomb T. Forgotten item Q2An Old Chest each floor (soul hearts, trinkets, items).
  20. 5Judgement T. Lazarus, Reversed Judgement cardA Shop Restock Machine on demand.
  21. 5The Sun and the Moon T. Jacob, Reversed Moon/Sun cardUltra Secret Room teleport and Spirit of the Night effects.
  22. 5Soul of Jacob and Esau T. Jacob runeTemporary Esau with random items.
  23. C Situational 3-4
  24. 4Wheel of Fortune T. Cain, Reversed Wheel of Fortune cardA random Dice Room effect.
  25. 4It’s the Key In-run, Ace of Spades cardTurns pickups and enemies into keys.
  26. 4Death T. Forgotten, Reversed Death cardKills spawn friendly Bonies.
  27. 4The Chariot Challenges, Reversed Chariot card10 s of invincibility with 4x fire rate.
  28. 4Hollow Heart T. Forgotten trinketAn empty Bone Heart every floor.
  29. 4Wooden Chest T. Lazarus unlockNew chest type with cards, pills or an item.
  30. 4Modeling Clay T. Eden trinketOften mimics a passive from the room’s pool.
  31. 35 Nights at Mom’s In-run, Super Special Rocks unlockRarer tinted rocks with more loot.
  32. 3Huge Growth In-run, Huge Growth card cardBecome huge and crush obstacles for a room.
  33. 3Ice Cube Challenges trinketChance to petrify enemies on room entry.
  34. 3Polished Bone T. Forgotten trinketFriendly Bonies on room clear.
  35. 3Dedication Daily, Horf! pill pillOne 200-damage explosive tear.
  36. 3Soul of ??? T. ??? runePoison farts and Butt Bombs.
  37. 3Ring Cap T. ??? trinketAn extra free bomb with every bomb.
  38. 3Found Soul T. Jacob trinketGhost familiar with half your damage.
  39. 3Esau Jr. T. Jacob item Q1Swap to a second body with flight and +2 damage.
  40. D Weak 1-2
  41. 2Stud Finder Challenges trinketTiny chance of Crawl Spaces from rocks.
  42. 2Decap Attack T. Forgotten item Q1Throwable head turret. Niche.
  43. 2Blue Key T. Cain trinketKey doors open free but through a long hallway.
  44. 2Torn Pocket T. Lazarus trinketHits drop pickups. Mostly a downside.
  45. 2RC Remote T. Jacob trinketFamiliars follow your inputs. Niche.
  46. 2Torn Card T. Lazarus trinketPeriodic returning explosive tear; can hurt you.
  47. 1Pica Run Challenges challengeUnlocks a challenge (its reward is Ice Cube).
  48. 1Temperance Challenges, Reversed Temperance cardEat 5 random pills. Risky.
  49. 1Golden Battery T. Forgotten unlockCharges but costs a full heart.
  50. 1TMTRAINER T. Eden item Q0Glitched items; fun chaos, usually a run-killer for marks.
  51. No item 0
  52. 0Play Online Online no itemAchievement only.
  53. 0Win Online Online no itemAchievement only.
  54. 0Dead God Final no itemAchievement only (bragging rights).
  55. 0Win Online Daily Online no itemAchievement only.

Reference

Rules shared by every run, what can block an unlock, open questions and all sources.

Tainted runs

How the unlocks work

  • Tainted characters have 12 marks but 7 unlocks. Isaac, ???, Satan and Lamb together give one unlock, Hush and Boss Rush also one, the rest one each: Mother, Beast, Delirium, Mega Satan, Ultra Greedier TCHCARGO2. Mom’s Heart and regular Greed give no unlock CM, but these marks are also needed for Death Certificate CARGO2.
  • Group unlocks accumulate across runs. I found no direct quote, but otherwise the four-boss unlock would be impossible: Isaac and Satan are on different branches, Cathedral and Sheol SHEOL.
  • A Hard mark also sets the Normal one CM. Ultra Greedier also counts Greed S-GR.
  • Victory Lap gives no marks VL. According to the Tainted Cain wiki page, four R Keys let you collect every mark except Greed in one run TC.
  • In co-op, marks and achievements go to all characters “regardless of how much they participated” COOP. A friend in local co-op can “carry” Tainted Jacob. The game draws online marks as a separate set: blue for Normal, purple for Hard CM. Whether they count toward Death Certificate is unconfirmed.

Template: 5 runs per character (my conclusion from the rules below)

  1. Run A: Cathedral
    1. Mom before 20:00
    2. Boss Rush
    3. Mom’s Heart/It Lives before 30:00
    4. Hush (skip the Void portal after Hush)
    5. Cathedral
    6. Isaac
    7. Chest (Polaroid needed)
    8. ???
    9. Mega Satan (Key Pieces needed)
    10. portal
    11. Delirium

    Marks Heart, Boss Rush, Hush, Isaac, ???, Mega Satan, Delirium

  2. Run B: Sheol
    1. Sheol
    2. Satan
    3. Dark Room (Negative needed)
    4. The Lamb

    if Mega Satan or Delirium failed in A, pick them up here

    Marks Satan, The Lamb

  3. Run C: Mother
    1. Downpour/Dross
    2. Mines/Ashpit
    3. Mausoleum/Gehenna (Mom before 25:00 → Boss Rush)
    4. Corpse
    5. Mother
    6. portal
    7. Delirium

    Marks Mother (+ Boss Rush, Delirium)

  4. Run D: Beast
    1. Mom on Depths II
    2. Strange Door
    3. Dad’s Note
    4. Ascent
    5. Home
    6. Dogma
    7. Beast

    Marks Beast (+ Boss Rush)

  5. Run E: Greed
    1. Greedier

    Marks Ultra Greedier

Run A gate

Run A chases seven marks at once. Check the in-game timer (Tab map) at each point; a miss changes the plan, not the run.

  • Depths II (Necropolis, Dank Depths) by 18:00, or Mausoleum/Gehenna II by 23:00: Mom has to die before 20:00 or 25:00 for Boss Rush BR. wiki
  • Womb II (Utero, Scarred Womb) by 28:00: Mom’s Heart or It Lives before 30:00 opens Hush BWOMB. wiki
  • By It Lives: the Polaroid for The Chest and ???, and both Key Pieces (or Dad’s Key) for Mega Satan MS. wiki
  • Missed a gate: do not restart. Bank what is still open (Isaac + ???). Mega Satan and Delirium move to Run B: in R+ the Void is guaranteed after ???, The Lamb and Mega Satan VOID. R+ patch
  • Weak build after Hush: skip Mega Satan, take Isaac → ??? and the guaranteed Void after ??? to Delirium. If Isaac and ??? are already done for this character, take the Void right after Hush VOID. R+ patch
  • Missed Boss Rush: it also fits Run C (Mom on Mausoleum II before 25:00) or D. Missed Hush: after Hush the way also leads to Sheol, so it fits Run B BRHUSH. wiki
  • Dad’s Key does not open expired doors: not Boss Rush after 20:00, not the Hush door after 30:00 DADKEY. Late for Hush: Mama Mega!, Mega Bean (R+) or Strange Key BRBWOMB; Tainted Cain crafts Mama Mega! from 8 Giga Bombs or 2 Golden Bombs + 6 Bombs BOC. wiki

Hush and Mother cannot be combined in one run, and the path to the Beast branches off at Depths II MAUSSD.

Timers and portals

  • Boss Rush: kill Mom before 20:00 on Depths/Necropolis/Dank Depths II or before 25:00 on Mausoleum/Gehenna II. If you entered the Devil Room after Mom, return to the boss room before 20:00 BR.
  • Hush: kill Mom’s Heart or It Lives! before 30:00. If you leave the room and return after 30:00, the entrance disappears BWOMB. Running late: Mama Mega! and Mega Bean (R+) open both entrances, and the Strange Key trinket also opens the Hush entrance BRBWOMB.
  • The timer is in-game time, visible on the expanded map (Tab) or with Extra HUD HUD. R Key does not reset it RKEY.
  • The Void: after Hush the portal is guaranteed. In R+ it is also guaranteed after ???, The Lamb, Mega Satan, and after Mother if her ending is already unlocked. After Isaac or Satan the chance is 15%, after Mom’s Heart/It Lives 10% VOID.
  • Mega Satan: you need Key Piece 1 (Uriel) and Key Piece 2 (Gabriel). The angels appear from a bombed Angel Statue or on the 9th and 11th spike hit in the Sacrifice Room. Alternatives: Dad’s Key, Get out of Jail Free Card, Mr. ME!, Sharp Key, Soul of Cain, Cracked Orb. In R+ the run continues after Mega Satan MS.
  • Path to Mother:
    1. The door after the Basement I/II boss (key needed) leads to Downpour/Dross DOWN.
    2. Knife Piece 1 is in the mirror world of Downpour/Dross II: the white fireplace turns you into the Lost, then through the mirror KP1.
    3. The boarded-up door in Mines/Ashpit opens with two bombs MINES.
    4. Knife Piece 2: press 3 yellow buttons, get into the minecart and escape Mother’s Shadow KP2.
    5. Entering Mausoleum/Gehenna costs 2 hearts. On Mausoleum II kill Mom, open the flesh door with the knife, then Mom’s Heart, Corpse I-II and Mother MAUS.
  • Path to the Beast: the Strange Door in the starting room of Depths II is opened by the Polaroid or Negative SDDAD. Only treasure and boss rooms remain on the Ascent, so it’s better not to take treasure rooms on the way down ASC.

Boss armor (Damage Scaling)

A strong build runs into a soft DPS cap. Bombs and most explosions bypass armor (except Dr. Fetus and Epic Fetus), and so does Dark Esau’s dash DSTJ.

BossArmorDPS Cap
Mother, phase 190≈24.7
Hush140≈47.6
Mega Satan90≈55.6
Ultra Greedier60≈41.7
The Beast60no data

Delirium only has armor while in the form of other bosses. In R+ Isaac, Satan and The Lamb received armor DS.

Ultra Greedier for everyone

Each floor has 9 waves, 2 boss waves and an optional nightmare wave GREED. At the end comes Ultra Greed first, then Ultra Greedier with 2500 HP UGR. Heart Coins heal the boss, you need to knock them away. If the room has many coins and monsters, Ultra Greed goes into a defensive stance UG. Plan C from the Greed Shop and Curse Room pools counts the kill, except for ghost characters PLANC. R+ added spawn indicators in Boss Rush and Greed (1.9.7.11) V1711.

What disables achievements

Achievements are disabled ACH:

  • in a run with an entered seed, except some special seeds; the blocking ones are marked “No unlocks” in the seed table SEEDS;
  • in a challenge (except its reward) and in the Daily (except Daily achievements);
  • with mods or the debug console, but only until Mom has been killed on the save without them; for you that’s long done ACHCONS;
  • in Victory Lap, except achievements for Victory Lap itself and U Broke It! VL;
  • for a player who joined an online run already in progress.

Sign that they’re disabled: a crossed-out trophy under the key counter ACH. The console command achievement unlocks Steam achievements irreversibly CONS; don’t touch it.

Tips for Hard

  1. Get all missing marks on Hard right away: a Hard mark also sets Normal CM and counts toward Death Certificate CARGO2.
  2. Combine goals using the template from Reference and don’t forget Delirium and Greedier S-DELFS-GR.
  3. On Hard, room clears drop 34% fewer hearts, curses are more frequent, and the shop is one level lower half the time HARD. Defensive items and saving health are worth more.
  4. Against armored bosses (Mother, Hush, Mega Satan), bombs and explosions are more effective than “strong” DPS DS.
  5. Hard characters can be carried in co-op: everyone gets the marks COOP.

Not confirmed

Save and marks

  • Whether online marks (blue and purple) count toward Death Certificate.
  • Whether a co-op character who became a ghost before the boss kill gets the mark.
  • Whether Mom’s Heart in the Mausoleum gives the Heart mark.

Daily and online

  • Whether online Dailies count toward Dedication, Broken Modem and The Marathon.
  • Whether a Beast Daily without a trophy counts toward Broken Modem.
  • Which time zone the Daily resets in and whether a solo Daily requires internet.
  • Whether one win in a Multiplayer Daily awards Play Online and Win Online at once.
  • Whether Steam lobbies, relay and Epic EOS work from Russia: there are no public reports, only complaints about lag with Zapret and GoodbyeDPI.

In-run achievements

  • 5 Nights at Mom’s: whether the Beast and Mega Satan endings count; whether the 5th win can be in Greed (2017 advice is contradictory); whether the “bitwise” pairs are fixed in R+; whether the “exit → challenge → new run” trick works.
  • Marbles: whether horse Gulp! counts as 2 in R+ and whether Echo Chamber repeats count.
  • Huge Growth: Leo (doesn’t count per Steam 2021) and Mega Mush.
  • It’s the Key: whether the G0NE S00N seed disables achievements; how Keeper behaves.
  • ZIP!: whether the timer runs while paused.

Characters

  • Whether Plan C works against Mother and Delirium in R+: the wiki contradicts itself.
  • Tainted Cain: how many pickups a pedestal gives; how D4 works in R+.
  • Tainted Eden: whether Holy Card and Wooden Cross cancel the reroll (probably yes).
  • Tainted Jacob: whether Esau appears in the Dogma and Beast fights; whether his damage scales.
  • Tainted Lazarus: whether the forms share coins, bombs and keys.

Other

  • Pica Run: in a wiki discussion (2021) someone wrote that the challenge unlocked only after Ultra Hard.
  • Dead God Tracker returned a 403 error; its capabilities are known only from a search snippet.

Sources

Codes in square brackets in the text point to these entries; tap one to see its links.

Wiki (bindingofisaacrebirth.wiki.gg)

Official Steam News (app 250900)

Steam Discussions (each link: https://steamcommunity.com/app/250900/discussions/0/ + number)

Guides and Tools

Videos (links only)

About this guide

Current as of 11.10.2026, Repentance+ v1.9.7.17 from 20.04.2026 VHV1717. Time and difficulty (★1-5) are my own estimates.

Conditions checked against the wiki achievement table CARGO1CARGO2. ★ means difficulty from 1 to 5.

Card tips, rewards and conditions also draw on the wiki Achievements (fandom) page (49 of 49 cards cite it, so the cards do not repeat it).